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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50110562
Substrate
n/a
Meas. Tech.
ChEBML_143686
IC50
12000±n/a nM
Citation
 Itani, H; Ito, H; Sakata, Y; Hatakeyama, Y; Oohashi, H; Satoh, Y Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett 12:799-802 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50110562
Synonyms:
5-Chloro-3-(2-{4-[(3-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-ylamino)-methyl]-piperidin-1-yl}-2-oxo-ethyl)-3H-benzothiazol-2-one | CHEMBL166606 | FR-233118
Type:
Small organic molecule
Emp. Form.:
C27H32ClN3O3S
Mol. Mass.:
514.079
SMILES:
COc1ccc2CCCC(Cc2c1)NCC1CCN(CC1)C(=O)Cn1c2cc(Cl)ccc2sc1=O
Structure:
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