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Target
Platelet glycoprotein VI
Ligand
BDBM250082
Substrate
n/a
Meas. Tech.
ChEMBL_2033139 (CHEMBL4687297)
IC50
510±n/a nM
Citation
 Foster, H; Wilson, C; Philippou, H; Foster, R Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. J Med Chem 63:12213-12242 (2020) [PubMed]  Article 
Target
Name:
Platelet glycoprotein VI
Synonyms:
GP6 | GPVI | GPVI_HUMAN | Glycoprotein 6 | Platelet glycoprotein VI
Type:
PROTEIN
Mol. Mass.:
36878.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109099
Residue:
339
Sequence:
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
  
Inhibitor
Name:
BDBM250082
Synonyms:
US9447106, 27b (peak 2) | US9556188, Compound 27a
Type:
Small organic molecule
Emp. Form.:
C27H29N5O3
Mol. Mass.:
471.5509
SMILES:
NC(=O)c1c2NCC[C@@H](C3CCN(CC3)C(=O)C=C)n2nc1-c1ccc(Oc2ccccc2)cc1 |r|
Structure:
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