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Target
Tryptase beta-2
Ligand
BDBM50112064
Substrate
n/a
Meas. Tech.
ChEBML_210836
Ki
10±n/a nM
Citation
 Schaschke, N; Dominik, A; Matschiner, G; Sommerhoff, CP Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors. Bioorg Med Chem Lett 12:985-8 (2002) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50112064
Synonyms:
3-(3-Aminomethyl-phenyl)-2-(3-{2-[(2R,5S)-5-({2-[2-(3-aminomethyl-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-ethylcarbamoyl}-methyl)-3,6-dioxo-piperazin-2-yl]-acetylamino}-propionylamino)-propionic acid methyl ester | CHEMBL171905
Type:
Small organic molecule
Emp. Form.:
C36H48N8O10
Mol. Mass.:
752.8139
SMILES:
COC(=O)C(Cc1cccc(CN)c1)NC(=O)CCNC(=O)C[C@H]1NC(=O)[C@H](CC(=O)NCCC(=O)NC(Cc2cccc(CN)c2)C(=O)OC)NC1=O
Structure:
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