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Target
Tryptase beta-2
Ligand
BDBM50112070
Substrate
n/a
Meas. Tech.
ChEBML_210836
Ki
180±n/a nM
Citation
 Schaschke, N; Dominik, A; Matschiner, G; Sommerhoff, CP Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors. Bioorg Med Chem Lett 12:985-8 (2002) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50112070
Synonyms:
3-(3-Aminomethyl-phenyl)-2-{2-[2-((2R,5S)-5-{2-[2-(3-aminomethyl-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-ethyl}-3,6-dioxo-piperazin-2-yl)-acetylamino]-acetylamino}-propionic acid methyl ester | CHEMBL173659
Type:
Small organic molecule
Emp. Form.:
C33H43N7O9
Mol. Mass.:
681.736
SMILES:
COC(=O)C(Cc1cccc(CN)c1)NC(=O)CC[C@@H]1NC(=O)[C@@H](CC(=O)NCC(=O)NC(Cc2cccc(CN)c2)C(=O)OC)NC1=O
Structure:
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