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Target
Serine/threonine-protein kinase Nek2
Ligand
BDBM50553212
Substrate
n/a
Meas. Tech.
ChEMBL_2045427 (CHEMBL4700126)
IC50
10.0±n/a nM
Citation
 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Med Chem 11:707-731 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek2
Synonyms:
NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:
Enzyme
Mol. Mass.:
51776.96
Organism:
Homo sapiens (Human)
Description:
P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM50553212
Synonyms:
CHEMBL4763380
Type:
Small organic molecule
Emp. Form.:
C17H14N6O
Mol. Mass.:
318.3327
SMILES:
CN1CCc2ccc(Nc3nc(C#C)c4nc[nH]c4n3)cc2C1=O
Structure:
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