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Target
Serine/threonine-protein kinase Chk2
Ligand
BDBM50235361
Substrate
n/a
Meas. Tech.
ChEMBL_2045475 (CHEMBL4700174)
IC50
2600±n/a nM
Citation
 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Med Chem 11:707-731 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk2
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2
Type:
Protein
Mol. Mass.:
60908.59
Organism:
Homo sapiens (Human)
Description:
O96017
Residue:
543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  
Inhibitor
Name:
BDBM50235361
Synonyms:
CHEMBL4074015
Type:
Small organic molecule
Emp. Form.:
C13H10N6O2S
Mol. Mass.:
314.323
SMILES:
NS(=O)(=O)c1ccc(Nc2nc(C#C)c3nc[nH]c3n2)cc1
Structure:
Search PDB for entries with ligand similarity: