Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50113615
Substrate
n/a
Meas. Tech.
ChEMBL_69679 (CHEMBL682017)
IC50
215±n/a nM
Citation
 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wu, Y; Jia, ZJ; Zhang, P; Wang, L; Doughan, B; Su, T; Kanter, J; Woolfrey, J; Wong, P; Huang, B; Tran, K; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors. Bioorg Med Chem Lett 12:1511-5 (2002) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50113615
Synonyms:
(E)-3-(5-Carbamimidoyl-2-methoxy-phenyl)-N-(2'-sulfamoyl-biphenyl-4-yl)-acrylamide | CHEMBL287973
Type:
Small organic molecule
Emp. Form.:
C23H22N4O4S
Mol. Mass.:
450.51
SMILES:
COc1ccc(cc1\C=C/C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(N)=N
Structure:
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