Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50113773
Substrate
n/a
Meas. Tech.
ChEMBL_103857 (CHEMBL712975)
IC50
>50000±n/a nM
Citation
 Dios, A; Mitchell, RA; Aljabari, B; Lubetsky, J; O'Connor, K; Liao, H; Senter, PD; Manogue, KR; Lolis, E; Metz, C; Bucala, R; Callaway, DJ; Al-Abed, Y Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. J Med Chem 45:2410-6 (2002) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50113773
Synonyms:
2-[(4-Hydroxy-benzylidene)-amino]-3-(1H-indol-3-yl)-propionic acid methyl ester | CHEMBL312502
Type:
Small organic molecule
Emp. Form.:
C19H18N2O3
Mol. Mass.:
322.3578
SMILES:
COC(=O)[C@@H](Cc1c[nH]c2ccccc12)\N=C\c1ccc(O)cc1
Structure:
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