Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50114025
Substrate
n/a
Meas. Tech.
ChEMBL_214412 (CHEMBL820276)
Ki
2.12±n/a nM
Citation
 Kakefuda, A; Suzuki, T; Tobe, T; Tsukada, J; Tahara, A; Sakamoto, S; Tsukamoto, S Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor. J Med Chem 45:2589-98 (2002) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50114025
Synonyms:
4-{4-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4-yl)-phenoxy]-butyl}-piperidine | CHEMBL432375
Type:
Small organic molecule
Emp. Form.:
C30H34N4O
Mol. Mass.:
466.6172
SMILES:
Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1OCCCCC1CCNCC1 |(10.8,-.03,;9.42,-.73,;8.13,.11,;6.93,-.86,;7.49,-2.29,;6.65,-3.59,;5.11,-3.5,;4.27,-4.8,;4.97,-6.16,;6.51,-6.25,;7.35,-4.96,;4.13,-7.44,;4.83,-8.82,;3.99,-10.11,;2.45,-10.03,;1.76,-8.65,;2.59,-7.36,;9.02,-2.22,;10.03,-3.36,;9.54,-4.82,;10.56,-5.97,;12.07,-5.66,;12.55,-4.19,;11.54,-3.05,;12.01,-1.59,;13.38,-.92,;14.67,-1.76,;16.04,-1.08,;17.32,-1.93,;17.23,-3.46,;18.55,-4.27,;18.49,-5.81,;17.14,-6.53,;15.83,-5.73,;15.88,-4.2,)|
Structure:
Search PDB for entries with ligand similarity: