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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM50553783
Substrate
n/a
Meas. Tech.
ChEMBL_2047190 (CHEMBL4701889)
IC50
11±n/a nM
Citation
 LaMarche, MJ; Acker, M; Argintaru, A; Bauer, D; Boisclair, J; Chan, H; Chen, CH; Chen, YN; Chen, Z; Deng, Z; Dore, M; Dunstan, D; Fan, J; Fekkes, P; Firestone, B; Fodor, M; Garcia-Fortanet, J; Fortin, PD; Fridrich, C; Giraldes, J; Glick, M; Grunenfelder, D; Hao, HX; Hentemann, M; Ho, S; Jouk, A; Kang, ZB; Karki, R; Kato, M; Keen, N; Koenig, R; LaBonte, LR; Larrow, J; Liu, G; Liu, S; Majumdar, D; Mathieu, S; Meyer, MJ; Mohseni, M; Ntaganda, R; Palermo, M; Perez, L; Pu, M; Ramsey, T; Reilly, J; Sarver, P; Sellers, WR; Sendzik, M; Shultz, MD; Slisz, J; Slocum, K; Smith, T; Spence, S; Stams, T; Straub, C; Tamez, V; Toure, BB; Towler, C; Wang, P; Wang, H; Williams, SL; Yang, F; Yu, B; Zhang, JH; Zhu, S Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J Med Chem 63:13578-13594 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM50553783
Synonyms:
Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | Tno-155 | Tno155
Type:
Small organic molecule
Emp. Form.:
C18H24ClN7OS
Mol. Mass.:
421.947
SMILES:
C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N |r|
Structure:
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