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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM12576
Substrate
n/a
Meas. Tech.
ChEMBL_2048087 (CHEMBL4702786)
Ki
16±n/a nM
Citation
 Abdelmagid, WM; Mahmoodi, N; Tanner, ME A guanidinium-based inhibitor of a type I isopentenyl diphosphate isomerase. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
FPPS
Type:
PROTEIN
Mol. Mass.:
40961.27
Organism:
Leishmania major
Description:
ChEMBL_850739
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM12576
Synonyms:
Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1123
SMILES:
OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: