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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM25313
Substrate
n/a
Meas. Tech.
ChEMBL_2048087 (CHEMBL4702786)
Ki
91±n/a nM
Citation
 Abdelmagid, WM; Mahmoodi, N; Tanner, ME A guanidinium-based inhibitor of a type I isopentenyl diphosphate isomerase. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
FPPS
Type:
PROTEIN
Mol. Mass.:
40961.27
Organism:
Leishmania major
Description:
ChEMBL_850739
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM25313
Synonyms:
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid | Alendronate | CHEMBL870 | bisphosphonate, 65
Type:
Small organic molecule
Emp. Form.:
C4H13NO7P2
Mol. Mass.:
249.096
SMILES:
NCCCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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