Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50113286
Substrate
n/a
Meas. Tech.
ChEMBL_2048087 (CHEMBL4702786)
Ki
330±n/a nM
Citation
 Abdelmagid, WM; Mahmoodi, N; Tanner, ME A guanidinium-based inhibitor of a type I isopentenyl diphosphate isomerase. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
FPPS
Type:
PROTEIN
Mol. Mass.:
40961.27
Organism:
Leishmania major
Description:
ChEMBL_850739
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM50113286
Synonyms:
(1-Hydroxy-1-phosphono-undecyl)-phosphonic acid | 1-hydroxyundecane-1,1-diyldiphosphonic acid | CHEMBL298852 | undecane-1-hydroxy-1,1-bisphosphonate
Type:
Small organic molecule
Emp. Form.:
C11H26O7P2
Mol. Mass.:
332.2675
SMILES:
CCCCCCCCCCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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