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Target
Myeloperoxidase
Ligand
BDBM357629
Substrate
n/a
Meas. Tech.
ChEMBL_2048423 (CHEMBL4703122)
IC50
9500±n/a nM
Citation
 Shaw, SA; Vokits, BP; Dilger, AK; Viet, A; Clark, CG; Abell, LM; Locke, GA; Duke, G; Kopcho, LM; Dongre, A; Gao, J; Krishnakumar, A; Jusuf, S; Khan, J; Spronk, SA; Basso, MD; Zhao, L; Cantor, GH; Onorato, JM; Wexler, RR; Duclos, F; Kick, EK Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Myeloperoxidase
Synonyms:
1.11.2.2 | Mpo | Myeloperoxidase | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_MOUSE
Type:
PROTEIN
Mol. Mass.:
81213.01
Organism:
Mus musculus
Description:
ChEMBL_10568
Residue:
718
Sequence:
MKLLLALAGLLAPLAMLQTSNGATPALLGEVENSVVLSCMEEAKQLVDRAYKERRESIKRSLQSGSASPTELLFYFKQPVAGTRTAVRAADYLHVALDLLKRKLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVRVTCPPNDKYRTITGHCNNRRSPTLGASNRAFVRWLPAEYEDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTKDQERALMFMQWGQFLDHDITLTPEPATRFSFFTGLNCETSCLQQPPCFPLKIPPNDPRIKNQKDCIPFFRSCPACTRNNITIRNQINALTSFVDASGVYGSEDPLARKLRNLTNQLGLLAINTRFQDNGRALMPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRLATQLKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYLPQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLNNQYRPTGPNPRVPLSKVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIVVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALASISLPRIICDNTGITTVSKNNIFMSNTYPRDFVSCNTLPKLNLTSWKET
  
Inhibitor
Name:
BDBM357629
Synonyms:
7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | US10214527, Example 1
Type:
Small organic molecule
Emp. Form.:
C12H11N5
Mol. Mass.:
225.2492
SMILES:
Nc1cc(Cc2ccccc2)c2nn[nH]c2n1
Structure:
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