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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50116231
Substrate
n/a
Meas. Tech.
ChEBML_71597
Ki
150±n/a nM
Citation
 Gross, TD; Zhu, YF; Saunders, J; Wilcoxen, KM; Gao, Y; Connors, PJ; Guo, Z; Struthers, RS; Reinhart, GJ; Chen, C Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. Bioorg Med Chem Lett 12:2185-7 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50116231
Synonyms:
6-Benzo[1,3]dioxol-5-yl-8-(2-fluoro-benzyl)-3-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-2-(4-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one | CHEMBL66808
Type:
Small organic molecule
Emp. Form.:
C33H33FN4O5
Mol. Mass.:
584.6373
SMILES:
COCCN(C)Cc1c(nc2n(Cc3ccccc3F)c(C)c(-c3ccc4OCOc4c3)c(=O)n12)-c1ccc(OC)cc1
Structure:
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