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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50116236
Substrate
n/a
Meas. Tech.
ChEBML_71597
Ki
140±n/a nM
Citation
 Gross, TD; Zhu, YF; Saunders, J; Wilcoxen, KM; Gao, Y; Connors, PJ; Guo, Z; Struthers, RS; Reinhart, GJ; Chen, C Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. Bioorg Med Chem Lett 12:2185-7 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50116236
Synonyms:
8-(2-Fluoro-benzyl)-2-(4-methoxy-phenyl)-7-methyl-3-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-6-(3-trifluoromethyl-phenyl)-8H-imidazo[1,2-a]pyrimidin-5-one | CHEMBL67820
Type:
Small organic molecule
Emp. Form.:
C37H33F4N5O2
Mol. Mass.:
655.6838
SMILES:
COc1ccc(cc1)-c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(c3)C(F)(F)F)c(=O)n2c1CN(C)CCc1ccccn1
Structure:
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