Reaction Details Report a problem with these data
Target
Anoctamin-2
Ligand
BDBM50556199
Substrate
n/a
Meas. Tech.
ChEMBL_2055562 (CHEMBL4710563)
IC50
15430±n/a nM
Citation
 Choi, SH; Ryu, S; Sim, K; Song, C; Shin, I; Kim, SS; Lee, YS; Park, JY; Sim, T Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
Anoctamin-2
Synonyms:
ANO2_MOUSE | Ano2 | Anoctamin-2 | Synonyms=Tmem16b | Tmem16b | Transmembrane protein 16B
Type:
PROTEIN
Mol. Mass.:
114143.50
Organism:
Mus musculus
Description:
ChEMBL_120162
Residue:
1002
Sequence:
MAAPGLRDIPLLPGSPRRLSSRTVARGSQGPKHGQQYLKVPGHRAPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPPSSEARLSRMHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLDALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEMCDHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDLDHSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKVKLADEPTQRSQGGGDRSRRSRAASSAPSGRSQPGSIASSGSQHTNV
  
Inhibitor
Name:
BDBM50556199
Synonyms:
CHEMBL4747471
Type:
Small organic molecule
Emp. Form.:
C18H28N2O2S
Mol. Mass.:
336.492
SMILES:
CC(C)(C)C1CCc2c(C1)sc(NC(=O)C(C)(C)C)c2C(N)=O
Structure:
Search PDB for entries with ligand similarity: