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Target
Lactoylglutathione lyase
Ligand
BDBM50556278
Substrate
n/a
Meas. Tech.
ChEMBL_2055825 (CHEMBL4710826)
IC50
13200±n/a nM
Citation
 Gavara, L; Sevaille, L; De Luca, F; Mercuri, P; Bebrone, C; Feller, G; Legru, A; Cerboni, G; Tanfoni, S; Baud, D; Cutolo, G; Bestgen, B; Chelini, G; Verdirosa, F; Sannio, F; Pozzi, C; Benvenuti, M; Kwapien, K; Fischer, M; Becker, K; Frère, JM; Mangani, S; Gresh, N; Berthomieu, D; Galleni, M; Docquier, JD; Hernandez, JF 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-?-lactamase inhibitors. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Human
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50556278
Synonyms:
CHEMBL4754312
Type:
Small organic molecule
Emp. Form.:
C20H14N4O2S
Mol. Mass.:
374.416
SMILES:
OC(=O)c1ccccc1\C=N\n1c(n[nH]c1=S)-c1ccc2ccccc2c1
Structure:
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