Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50556595
Substrate
n/a
Meas. Tech.
ChEMBL_2056687 (CHEMBL4711688)
IC50
0.320000±n/a nM
Citation
 Jiang, X; Zhou, T; Bai, R; Xie, Y Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities. J Med Chem 63:14470-14501 (2020) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50556595
Synonyms:
CHEMBL4740154
Type:
Small organic molecule
Emp. Form.:
C13H18N2O2
Mol. Mass.:
234.2942
SMILES:
CN(CCCn1ccc(=O)c(O)c1C)CC#C
Structure:
Search PDB for entries with ligand similarity: