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Target
Acyl-protein thioesterase 1
Ligand
BDBM50009366
Substrate
n/a
Meas. Tech.
ChEMBL_2059145 (CHEMBL4714146)
IC50
3.3±n/a nM
Citation
 Jung, HJ; Nam, EH; Park, JY; Ghosh, P; Kim, IS Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. Bioorg Med Chem Lett 37:0 (2021) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50009366
Synonyms:
CHEMBL3233842 | US11504364, Compound Ref.-Comp. | US9346814, Cmpd No 1, Example 1
Type:
Small organic molecule
Emp. Form.:
C17H14F2N4O2
Mol. Mass.:
344.3155
SMILES:
FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12 |r|
Structure:
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