Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 1
Ligand
BDBM50557419
Substrate
n/a
Meas. Tech.
ChEMBL_2059145 (CHEMBL4714146)
IC50
47±n/a nM
Citation
 Jung, HJ; Nam, EH; Park, JY; Ghosh, P; Kim, IS Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. Bioorg Med Chem Lett 37:0 (2021) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50557419
Synonyms:
CHEMBL4748332
Type:
Small organic molecule
Emp. Form.:
C18H14F4N4O2S
Mol. Mass.:
426.388
SMILES:
Fc1ccc(Cc2nc(cs2)C(=O)NCC(=O)N2CC(F)(F)C[C@H]2C#N)cc1F |r|
Structure:
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