Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50119184
Substrate
n/a
Meas. Tech.
ChEMBL_38295 (CHEMBL647099)
EC50
>1000±n/a nM
Citation
 Steffan, RJ; Ashwell, MA; Solvibile, WR; Matelan, E; Largis, E; Han, S; Tillet, J; Mulvey, R Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines. Bioorg Med Chem Lett 12:2957-61 (2002) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50119184
Synonyms:
1-[(S)-4-(4-{[3-(9H-Carbazol-4-yloxy)-2-hydroxy-propylamino]-methyl}-piperidine-1-sulfonyl)-phenyl]-3-hexyl-urea | CHEMBL319409
Type:
Small organic molecule
Emp. Form.:
C34H45N5O5S
Mol. Mass.:
635.817
SMILES:
CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(CNC[C@H](O)COc2cccc3[nH]c4ccccc4c23)CC1
Structure:
Search PDB for entries with ligand similarity: