Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50119931
Substrate
n/a
Meas. Tech.
ChEMBL_58962 (CHEMBL669519)
Ki
36±n/a nM
Citation
Zhao, H; Thurkauf, A; He, X; Hodgetts, K; Zhang, X; Rachwal, S; Kover, RX; Hutchison, A; Peterson, J; Kieltyka, A; Brodbeck, R; Primus, R; Wasley, JW Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships. Bioorg Med Chem Lett 12:3105-9 (2002) [PubMed] Article
More Info.:
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Inhibitor
Name:
BDBM50119931
Synonyms:
2-[4-(4-chlorobenzyl)hexahydro-1-pyrazinyl]-1-spiro[cyclopentane-1,2'-(2',3'-dihydro-1'H-indole)]-1-yl-1-ethanone | CHEMBL441274
Type:
Small organic molecule
Emp. Form.:
C25H30ClN3O
Mol. Mass.:
423.978
SMILES:
Clc1ccc(CN2CCN(CC(=O)N3c4ccccc4CC33CCCC3)CC2)cc1