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Target
DNA-3-methyladenine glycosylase
Ligand
BDBM26658
Substrate
n/a
Meas. Tech.
ChEMBL_2070259 (CHEMBL4725793)
IC50
2600±n/a nM
Citation
 Mas Claret, E; Al Yahyaei, B; Chu, S; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG). Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
DNA-3-methyladenine glycosylase
Synonyms:
3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | 3MG_HUMAN | AAG | ADPG | ANPG | MID1 | MPG | N-methylpurine-DNA glycosylase
Type:
PROTEIN
Mol. Mass.:
32883.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109564
Residue:
298
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
  
Inhibitor
Name:
BDBM26658
Synonyms:
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one | CHEMBL28626 | MLS000069618 | Morin (19) | Morin (5) | Morin (Mor) | SMR000058259 | cid_5281670 | morin
Type:
Flavonoid
Emp. Form.:
C15H10O7
Mol. Mass.:
302.2357
SMILES:
Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Structure:
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