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Target
DNA-3-methyladenine glycosylase
Ligand
BDBM50559764
Substrate
n/a
Meas. Tech.
ChEMBL_2070259 (CHEMBL4725793)
IC50
157000±n/a nM
Citation
 Mas Claret, E; Al Yahyaei, B; Chu, S; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK An aza-nucleoside, fragment-like inhibitor of the DNA repair enzyme alkyladenine glycosylase (AAG). Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
DNA-3-methyladenine glycosylase
Synonyms:
3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | 3MG_HUMAN | AAG | ADPG | ANPG | MID1 | MPG | N-methylpurine-DNA glycosylase
Type:
PROTEIN
Mol. Mass.:
32883.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109564
Residue:
298
Sequence:
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRERCLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
  
Inhibitor
Name:
BDBM50559764
Synonyms:
CHEMBL4751946
Type:
Small organic molecule
Emp. Form.:
C9H15N3O2
Mol. Mass.:
197.2343
SMILES:
OC[C@H]1CN(Cc2c[nH]cn2)C[C@@H]1O |r|
Structure:
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