Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50122425
Substrate
n/a
Meas. Tech.
ChEBML_1232
IC50
50±n/a nM
Citation
 Mattson, RJCatt, JDSloan, CPGao, QCarter, RBGentile, AMahle, CDMatos, FFMcGovern, RVanderMaelen, CPYocca, FD Development of a presynaptic 5-HT1A antagonist. Bioorg Med Chem Lett 13:285-8 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50122425
Synonyms:
4-(4-Benzyl-piperazin-1-yl)-1-(3-methoxy-phenyl)-cyclohexanol | CHEMBL95860
Type:
Small organic molecule
Emp. Form.:
C24H32N2O2
Mol. Mass.:
380.5231
SMILES:
COc1cccc(c1)C1(O)CCC(CC1)N1CCN(Cc2ccccc2)CC1 |(-1.3,2.54,;.24,2.51,;.99,1.17,;.21,-.16,;.98,-1.5,;2.5,-1.5,;3.29,-.17,;2.53,1.16,;4.83,-.19,;5.23,1.3,;5.09,-1.73,;6.93,-1.73,;7.91,-2.53,;7.64,-.99,;5.88,-1.03,;9.45,-2.53,;10.22,-3.86,;11.74,-3.86,;12.51,-2.53,;14.05,-2.53,;14.82,-3.86,;16.36,-3.86,;17.13,-5.18,;16.36,-6.52,;14.82,-6.52,;14.05,-5.19,;11.74,-1.2,;10.2,-1.2,)|
Structure:
Search PDB for entries with ligand similarity: