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Target
Carnitine O-palmitoyltransferase 1, muscle isoform
Ligand
BDBM50101591
Substrate
n/a
Meas. Tech.
ChEMBL_46329 (CHEMBL874517)
IC50
5800±n/a nM
Citation
 Giannessi, F; Pessotto, P; Tassoni, E; Chiodi, P; Conti, R; De Angelis, F; Dell'Uomo, N; Catini, R; Deias, R; Tinti, MO; Carminati, P; Arduini, A Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity. J Med Chem 46:303-9 (2003) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, muscle isoform
Synonyms:
CPT1B_RAT | Carnitine palmitoyltransferase 1B | Cpt1b
Type:
PROTEIN
Mol. Mass.:
88241.28
Organism:
Rattus norvegicus
Description:
ChEMBL_887447
Residue:
772
Sequence:
MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQTETLLSMVIFSTGVWATGIFLFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMESLAKEFQDKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSNYYAMDFVLIKNTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALTAGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYNRWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEPNTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADHGYGVSYMIAGENTMFFHVSSKLSSSETNALRFGNHIRQALLDIADLFKISKTDS
  
Inhibitor
Name:
BDBM50101591
Synonyms:
CHEMBL308869 | R-[3-Carboxy-2-(undecane-1-sulfamoylamino)-propyl]-trimethyl-ammonium | [3-Carboxy-2-(undecylaminosulphonyl-amino)-propyl]-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C18H39N3O4S
Mol. Mass.:
393.585
SMILES:
CCCCCCCCCCCNS(=O)(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Structure:
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