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Target
Carnitine O-palmitoyltransferase 1, liver isoform
Ligand
BDBM50122828
Substrate
n/a
Meas. Tech.
ChEMBL_46326 (CHEMBL660894)
IC50
3200±n/a nM
Citation
 Giannessi, F; Pessotto, P; Tassoni, E; Chiodi, P; Conti, R; De Angelis, F; Dell'Uomo, N; Catini, R; Deias, R; Tinti, MO; Carminati, P; Arduini, A Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity. J Med Chem 46:303-9 (2003) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, liver isoform
Synonyms:
CPT I | CPT1-L | CPT1A_RAT | CPTI-L | Carnitine O-palmitoyltransferase I, liver isoform | Carnitine palmitoyltransferase 1A | Cpt-1 | Cpt1 | Cpt1a
Type:
PROTEIN
Mol. Mass.:
88147.11
Organism:
Rattus norvegicus
Description:
ChEMBL_887445
Residue:
773
Sequence:
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
  
Inhibitor
Name:
BDBM50122828
Synonyms:
CHEMBL106274 | [3-Carboxy-2-(3-undecyl-ureido)-propyl]-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C19H39N3O3
Mol. Mass.:
357.5313
SMILES:
CCCCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C
Structure:
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