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Target
Histone deacetylase 1
Ligand
BDBM50123978
Substrate
n/a
Meas. Tech.
ChEMBL_87856 (CHEMBL877713)
IC50
3000±n/a nM
Citation
 Bouchain, G; Leit, S; Frechette, S; Khalil, EA; Lavoie, R; Moradei, O; Woo, SH; Fournel, M; Yan, PT; Kalita, A; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Robert, MF; MacLeod, AR; Besterman, JM; Delorme, D Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. J Med Chem 46:820-30 (2003) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50123978
Synonyms:
CHEMBL169352 | N-(2-Amino-phenyl)-3-[4-(naphthalene-1-sulfonylamino)-phenyl]-acrylamide | US8796330, 107
Type:
Small organic molecule
Emp. Form.:
C25H21N3O3S
Mol. Mass.:
443.518
SMILES:
Nc1ccccc1NC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1
Structure:
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