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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM50561427
Substrate
n/a
Meas. Tech.
ChEMBL_2074965 (CHEMBL4730499)
Ki
1259±n/a nM
Citation
 Gunera, J; Baker, JG; van Hilten, N; Rosenbaum, DM; Kolb, P Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. J Med Chem 63:11045-11053 (2020) [PubMed]  Article 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM50561427
Synonyms:
CHEMBL4759509
Type:
Small organic molecule
Emp. Form.:
C23H20FN3O2
Mol. Mass.:
389.4222
SMILES:
Cc1nc2cc(F)cc(C(=O)NCCOc3ccc4ccccc4c3)c2nc1C
Structure:
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