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Target
Synaptic vesicular amine transporter
Ligand
BDBM50561748
Substrate
n/a
Meas. Tech.
ChEMBL_2075821 (CHEMBL4731355)
Ki
160±n/a nM
Citation
 Shanu-Wilson, J; Evans, L; Wrigley, S; Steele, J; Atherton, J; Boer, J Biotransformation: Impact and Application of Metabolism in Drug Discovery. ACS Med Chem Lett 11:2087-2107 (2020) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rattus norvegicus (Rat)
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50561748
Synonyms:
CHEMBL4752068
Type:
Small organic molecule
Emp. Form.:
C24H38N2O5
Mol. Mass.:
434.5689
SMILES:
[H][C@]12C[C@@H](OC(=O)[C@@H](N)C(C)(C)O)[C@H](CC(C)C)CN1CCc1cc(OC)c(OC)cc21 |r|
Structure:
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