Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50125236
Substrate
n/a
Meas. Tech.
ChEBML_69674
Ki
3.3±n/a nM
Citation
Quan, ML; Ellis, CD; He, MY; Liauw, AY; Lam, PY; Rossi, KA; Knabb, RM; Luettgen, JM; Wright, MR; Wong, PC; Wexler, RR Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 13:1023-8 (2003) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50125236
Synonyms:
3-(3-Amino-4-chloro-phenyl)-5-[(2,2,2-trifluoro-ethanesulfonylamino)-methyl]-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide | CHEMBL269393
Type:
Small organic molecule
Emp. Form.:
C24H22ClF3N6O6S2
Mol. Mass.:
647.046
SMILES:
Nc1cc(ccc1Cl)C1=NOC(CNS(=O)(=O)CC(F)(F)F)(C1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O |t:9|