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Target
Hormone-sensitive lipase
Ligand
BDBM50125740
Substrate
n/a
Meas. Tech.
ChEMBL_88053 (CHEMBL693216)
IC50
200±n/a nM
Citation
 Slee, DH; Bhat, AS; Nguyen, TN; Kish, M; Lundeen, K; Newman, MJ; McConnell, SJ Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase. J Med Chem 46:1120-2 (2003) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN
Type:
Protein
Mol. Mass.:
116599.07
Organism:
Homo sapiens (Human)
Description:
Q05469
Residue:
1076
Sequence:
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
  
Inhibitor
Name:
BDBM50125740
Synonyms:
8a-Benzyloxymethyl-6-furan-2-yl-1,4-dioxo-2-(4-phenyl-butyl)-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester | CHEMBL268994
Type:
Small organic molecule
Emp. Form.:
C34H40N2O6
Mol. Mass.:
572.6912
SMILES:
CC(C)(C)OC(=O)C1CC2(COCc3ccccc3)N(C1c1ccco1)C(=O)CN(CCCCc1ccccc1)C2=O
Structure:
Search PDB for entries with ligand similarity: