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Target
Lanosterol 14-alpha demethylase
Ligand
BDBM50562436
Substrate
n/a
Meas. Tech.
ChEMBL_2078659 (CHEMBL4734450)
IC50
1153±n/a nM
Citation
 An, Y; Dong, Y; Liu, M; Han, J; Zhao, L; Sun, B Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation. Eur J Med Chem 210:0 (2021) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha demethylase
Synonyms:
1.14.14.154 | CP51_CANAL | CYP51 | CYPLI | Cytochrome P450 51 | Cytochrome P450-14DM | Cytochrome P450-LIA1 | ERG11 | ERG16 | ERG16 | Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase
Type:
PROTEIN
Mol. Mass.:
60679.24
Organism:
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Description:
ChEMBL_58
Residue:
528
Sequence:
MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF
  
Inhibitor
Name:
BDBM50562436
Synonyms:
CHEMBL4764357
Type:
Small organic molecule
Emp. Form.:
C23H21N5O2
Mol. Mass.:
399.4451
SMILES:
O=C(NCc1ccncc1)C(Cn1ccnc1)NC(=O)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: