Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50247053
Substrate
n/a
Meas. Tech.
ChEMBL_2079147 (CHEMBL4734938)
Ki
17±n/a nM
Citation
 Szczepa?ska, K; Pockes, S; Podlewska, S; Höring, C; Mika, K; Latacz, G; Bednarski, M; Siwek, A; Karcz, T; Nagl, M; Bresinsky, M; Mönnich, D; Seibel, U; Kuder, KJ; Kota?ska, M; Stark, H; Elz, S; Kie?-Kononowicz, K Structural modifications in the distal, regulatory region of histamine H Eur J Med Chem 213:0 (2021) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50247053
Synonyms:
1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine | CHEMBL462605 | Tiprolisant
Type:
Small organic molecule
Emp. Form.:
C17H26ClNO
Mol. Mass.:
295.847
SMILES:
Clc1ccc(CCCOCCCN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: