Reaction Details Report a problem with these data
Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50126207
Substrate
n/a
Meas. Tech.
ChEBML_123010
IC50
21±n/a nM
Citation
Magnin, DR; Biller, SA; Wetterau, J; Robl, JA; Dickson, JK; Taunk, P; Harrity, TW; Lawrence, RM; Sun, CQ; Wang, T; Logan, J; Fryszman, O; Connolly, F; Jolibois, K; Kunselman, L Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents. Bioorg Med Chem Lett 13:1337-40 (2003) [PubMed] Article
More Info.:
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_BOVIN | MTTP
Type:
PROTEIN
Mol. Mass.:
99049.43
Organism:
Bos taurus
Description:
ChEMBL_123010
Residue:
887
Sequence:
FLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF
Inhibitor
Name:
BDBM50126207
Synonyms:
(4-{9-[2-(4-Methoxy-phenyl)-ethylcarbamoyl]-9H-fluoren-9-yl}-butyl)-phosphonic acid dibutyl ester | CHEMBL281732
Type:
Small organic molecule
Emp. Form.:
C35H46NO5P
Mol. Mass.:
591.7172
SMILES:
CCCCOP(=O)(CCCCC1(C(=O)NCCc2ccc(OC)cc2)c2ccccc2-c2ccccc12)OCCCC