Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50126660
Substrate
n/a
Meas. Tech.
ChEMBL_163994 (CHEMBL766521)
IC50
11000±n/a nM
Citation
Chan, L; Reddy, TJ; Proulx, M; Das, SK; Pereira, O; Wang, W; Siddiqui, A; Yannopoulos, CG; Poisson, C; Turcotte, N; Drouin, A; Alaoui-Ismaili, MH; Bethell, R; Hamel, M; L'Heureux, L; Bilimoria, D; Nguyen-Ba, N Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase. J Med Chem 46:1283-5 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50126660
Synonyms:
(S)-2-(2,4-dichloro-N-(pyridin-3-ylmethyl)benzamido)-3-phenylpropanoic acid | 2-[(2,4-Dichloro-benzoyl)-pyridin-3-ylmethyl-amino]-3-phenyl-propionic acid | CHEMBL283833
Type:
Small organic molecule
Emp. Form.:
C22H18Cl2N2O3
Mol. Mass.:
429.296
SMILES:
OC(=O)[C@H](Cc1ccccc1)N(Cc1cccnc1)C(=O)c1ccc(Cl)cc1Cl |r|