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Target
Protein phosphatase 1G
Ligand
BDBM50564158
Substrate
n/a
Meas. Tech.
ChEMBL_2086939 (CHEMBL4768202)
IC50
138500±n/a nM
Citation
 Hou, X; Sun, JP; Ge, L; Liang, X; Li, K; Zhang, Y; Fang, H Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets. Eur J Med Chem 190:0 (2020) [PubMed]  Article 
Target
Name:
Protein phosphatase 1G
Synonyms:
PP2C-gamma | PPM1C | PPM1G | PPM1G_HUMAN | Protein phosphatase 1C | Protein phosphatase 1G | Protein phosphatase 2C isoform gamma | Protein phosphatase magnesium-dependent 1 gamma
Type:
PROTEIN
Mol. Mass.:
59199.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109523
Residue:
546
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD
  
Inhibitor
Name:
BDBM50564158
Synonyms:
CHEMBL4794022
Type:
Small organic molecule
Emp. Form.:
C25H20BrClN2O4S
Mol. Mass.:
559.859
SMILES:
OC(=O)c1cccc2C3C(Cl)C(CC3C(Nc12)c1cccc(Br)c1)Sc1ccccc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: