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Target
Carbonic anhydrase 9
Ligand
BDBM50564901
Substrate
n/a
Meas. Tech.
ChEMBL_2089635 (CHEMBL4770898)
Ki
2254±n/a nM
Citation
 Elzahhar, PA; Abd El Wahab, SM; Elagawany, M; Daabees, H; Belal, ASF; El-Yazbi, AF; Eid, AH; Alaaeddine, R; Hegazy, RR; Allam, RM; Helmy, MW; Bahaa Elgendy, na; Angeli, A; El-Hawash, SA; Supuran, CT Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases. Eur J Med Chem 200:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 9
Synonyms:
CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250
Type:
Enzyme
Mol. Mass.:
49669.03
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
459
Sequence:
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
  
Inhibitor
Name:
BDBM50564901
Synonyms:
CHEMBL4781301
Type:
Small organic molecule
Emp. Form.:
C20H16N6O3
Mol. Mass.:
388.3794
SMILES:
Cc1c(nnn1-c1ccc(cc1)C(O)=O)-c1nn(cc1\C=N\O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: