Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50131200
Substrate
n/a
Meas. Tech.
ChEBML_44674
IC50
830.0±n/a nM
Citation
 Baxter, A; Bennion, C; Bent, J; Boden, K; Brough, S; Cooper, A; Kinchin, E; Kindon, N; McInally, T; Mortimore, M; Roberts, B; Unitt, J Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists. Bioorg Med Chem Lett 13:2625-8 (2003) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50131200
Synonyms:
2-Benzyl-5-(4-chloro-phenyl)-2H-[1,2,4]triazole-3-thiol | CHEMBL86284
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3S
Mol. Mass.:
301.794
SMILES:
Clc1ccc(cc1)-c1nn(Cc2ccccc2)c(=S)[nH]1
Structure:
Search PDB for entries with ligand similarity: