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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50131658
Substrate
n/a
Meas. Tech.
ChEMBL_201336 (CHEMBL806185)
IC50
4000±n/a nM
Citation
 Meltzer, PC; Blundell, P; Zona, T; Yang, L; Huang, H; Bonab, AA; Livni, E; Fischman, A; Madras, BK A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem 46:3483-96 (2003) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50131658
Synonyms:
CHEMBL117362 | N-[ (2-( ( 3'-N-propyl-( 1''R) -3''beta- (4-fluorophenyl) trop-2''-ene-2''--carbomethoxy) (2-mercaptoethyl) amino) acetyl) -2-aminoethanethiolato)rhenium(V) oxide
Type:
Small organic molecule
Emp. Form.:
C24H31FN3O4ReS2
Mol. Mass.:
694.856
SMILES:
COC(=O)C1=C(CC2CCC1N2CCCN1CCS[Re]2(=O)SCCN2C(=O)C1)c1ccc(F)cc1 |t:4,THB:12:11:4.5.6:9.8,2:4:11:9.8|
Structure:
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