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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM91466
Substrate
n/a
Meas. Tech.
ChEMBL_2104316 (CHEMBL4812819)
IC50
23770±n/a nM
Citation
 Capochiani de Iudicibus, R; Tomek, P; Palmer, BD; Tijono, SM; Flanagan, JU; Ching, LM Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay. Bioorg Med Chem 39:0 (2021) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM91466
Synonyms:
10-(2-methoxyethyl)-3-phenyl-benzo[g]pteridine-2,4-dione | 10-(2-methoxyethyl)-3-phenyl-benzo[g]pteridine-2,4-quinone | 10-(2-methoxyethyl)-3-phenylbenzo[g]pteridine-2,4-dione | MLS003115591 | SMR001831164 | cid_324140
Type:
Small organic molecule
Emp. Form.:
C19H16N4O3
Mol. Mass.:
348.3553
SMILES:
COCCn1c2ccccc2nc2c1nc(=O)n(-c1ccccc1)c2=O
Structure:
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