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Target
Transthyretin
Ligand
BDBM67454
Substrate
n/a
Meas. Tech.
ChEMBL_2105310 (CHEMBL4813813)
IC50
12000±n/a nM
Citation
 Kitakami, R; Inui, K; Nakagawa, Y; Sawai, Y; Katayama, W; Yokoyama, T; Okada, T; Kanamitsu, K; Nakagawa, S; Toyooka, N; Mizuguchi, M Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg Med Chem 44:0 (2021) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM67454
Synonyms:
1,2,4-trihydroxy-9,10-anthraquinone | 1,2,4-trihydroxyanthracene-9,10-dione | 1,2,4-tris(oxidanyl)anthracene-9,10-dione | MLS002473304 | SMR001306802 | cid_6683 | hsp90_173 | purpurin
Type:
Small organic molecule
Emp. Form.:
C14H8O5
Mol. Mass.:
256.2103
SMILES:
Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O
Structure:
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