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Target
Proto-oncogene tyrosine-protein kinase LCK
Ligand
BDBM13219
Substrate
n/a
Meas. Tech.
ChEMBL_221476 (CHEMBL842063)
IC50
7500±n/a nM
Citation
 Wityak, J; Das, J; Moquin, RV; Shen, Z; Lin, J; Chen, P; Doweyko, AM; Pitt, S; Pang, S; Shen, DR; Fang, Q; de Fex, HF; Schieven, GL; Kanner, SB; Barrish, JC Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett 13:4007-10 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase LCK
Synonyms:
LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:
PROTEIN
Mol. Mass.:
57927.84
Organism:
Mus musculus
Description:
ChEMBL_806408
Residue:
509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM13219
Synonyms:
2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,6-dimethylphenyl)-1,3-thiazole-5-carboxamide | BMS-354825 tert-Butoxycarbamate Analog 5c | CHEMBL129454 | tert-butyl N-{5-[(2,6-dimethylphenyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}carbamate
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3S
Mol. Mass.:
361.459
SMILES:
Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C
Structure:
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