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Target
Tubulin alpha-1A chain
Ligand
BDBM50135662
Substrate
n/a
Meas. Tech.
ChEBML_212010
IC50
10000±n/a nM
Citation
 Xia, Y; Yang, ZY; Xia, P; Bastow, KF; Nakanishi, Y; Nampoothiri, P; Hamel, E; Brossi, A; Lee, KH Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters. Bioorg Med Chem Lett 13:2891-3 (2003) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50135662
Synonyms:
CHEMBL439958 | [2-(2-Fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-7-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C17H12FNO3
Mol. Mass.:
297.2805
SMILES:
OC(=O)Cc1ccc2c(O)cc(nc2c1)-c1ccccc1F
Structure:
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