Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50136947
Substrate
n/a
Meas. Tech.
ChEMBL_49306 (CHEMBL663405)
Ki
1400±n/a nM
Citation
 Ostrovsky, D; Udier-Blagovic, M; Jorgensen, WL Analyses of activity for factor Xa inhibitors based on Monte Carlo simulations. J Med Chem 46:5691-9 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50136947
Synonyms:
3-{3,5-Difluoro-4-methyl-6-[3-(2-oxo-propyl)-phenoxy]-pyridin-2-yloxy}-benzamidine | CHEMBL157316
Type:
Small organic molecule
Emp. Form.:
C22H19F2N3O3
Mol. Mass.:
411.4014
SMILES:
CC(=O)Cc1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1
Structure:
Search PDB for entries with ligand similarity: