Reaction Details Report a problem with these data
Target
Tripartite terminase subunit 3
Ligand
BDBM50571843
Substrate
n/a
Meas. Tech.
ChEMBL_2115650 (CHEMBL4824591)
IC50
3500±n/a nM
Citation
 Wang, L; Edwards, TC; Sahani, RL; Xie, J; Aihara, H; Geraghty, RJ; Wang, Z Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex. Eur J Med Chem 222:0 (2021) [PubMed]  Article 
Target
Name:
Tripartite terminase subunit 3
Synonyms:
3.1.-.- | TRM3 | TRM3_HCMVA | Terminase large subunit | Tripartite terminase subunit 3
Type:
PROTEIN
Mol. Mass.:
77099.22
Organism:
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:
ChEMBL_120506
Residue:
674
Sequence:
MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVATLCRKRYQMMHPELGLAHSCNEAFLPLMAFCGRHRDYNSPEESQRELLFHERLKSALDKLTFRPCSEEQRASYQKLDALTELYRDPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIFFIAVTKIPVLANRVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISFLLKHMIGISIGYVAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTALFASCYNTNSIRGQNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDSTCFLTRLNNAPFDMLNVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFMPGAFMDEIIGGTNKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTTNRKASGTGVAAVGAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDELRIAVEGNTNQAAAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVEQFISRFNSGYIKASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRISDDLIIAVIMATYLCDDIHAIRFRVS
  
Inhibitor
Name:
BDBM50571843
Synonyms:
CHEMBL4854031
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3
Mol. Mass.:
323.3459
SMILES:
Cc1ccc(c(C)c1)-c1cccc(Nc2cc(=O)n(O)c(=O)[nH]2)c1
Structure:
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