Reaction Details Report a problem with these data
Target
Polyprenyl synthetase family protein
Ligand
BDBM50117260
Substrate
n/a
Meas. Tech.
ChEMBL_69823 (CHEMBL679572)
IC50
310±n/a nM
Citation
Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem 47:175-87 (2003) [PubMed] Article
More Info.:
Target
Name:
Polyprenyl synthetase family protein
Synonyms:
Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase
Type:
PROTEIN
Mol. Mass.:
41078.35
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_330072
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTTQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKRQK
Inhibitor
Name:
BDBM50117260
Synonyms:
1-hydroxy-3-(methyl(phenethyl)amino)propane-1,1-diyldiphosphonic acid | CHEMBL301244 | [1-Hydroxy-3-(methyl-phenethyl-amino)-1-phosphono-propyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H21NO7P2
Mol. Mass.:
353.2452
SMILES:
CN(CCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O