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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50573682
Substrate
n/a
Meas. Tech.
ChEMBL_2120024 (CHEMBL4829171)
IC50
>30000±n/a nM
Citation
 Hartz, RA; Ahuja, VT; Nara, SJ; Kumar, CMV; Brown, JM; Bristow, LJ; Rajamani, R; Muckelbauer, JK; Camac, D; Kiefer, SE; Hunihan, L; Gulianello, M; Lewis, M; Easton, A; Lippy, JS; Surti, N; Pattipati, SN; Dokania, M; Elavazhagan, S; Dandapani, K; Hamman, BD; Allen, J; Kostich, W; Bronson, JJ; Macor, JE; Dzierba, CD Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain. J Med Chem 64:11090-11128 (2021) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
465
Sequence:
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50573682
Synonyms:
CHEMBL4872886
Type:
Small organic molecule
Emp. Form.:
C16H19F2N3O3
Mol. Mass.:
339.3372
SMILES:
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1 |r|
Structure:
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