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Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50140281
Substrate
n/a
Meas. Tech.
ChEBML_28895
IC50
770±n/a nM
Citation
 Kurata, H; Suzuki, S; Ohhata, Y; Ikeda, T; Hasegawa, T; Kitayama, K; Inaba, T; Kono, K; Kohama, T A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives. Bioorg Med Chem Lett 14:1183-6 (2004) [PubMed]  Article 
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2
Type:
Enzyme
Mol. Mass.:
37714.89
Organism:
Homo sapiens (Human)
Description:
SLC10A2
Residue:
348
Sequence:
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
  
Inhibitor
Name:
BDBM50140281
Synonyms:
1-{7-[3-[(3,5-Difluoro-phenyl)-ethyl-carbamoyl]-1-(3,5-dimethoxy-phenyl)-4-oxo-1,4-dihydro-quinolin-7-yloxy]-heptyl}-4-aza-1-azonia-bicyclo[2.2.2]octane; bromide | CHEMBL17966
Type:
Small organic molecule
Emp. Form.:
C39H47F2N4O5
Mol. Mass.:
689.8105
SMILES:
CCN(C(=O)c1cn(-c2cc(OC)cc(OC)c2)c2cc(OCCCCCCC[N+]34CCN(CC3)CC4)ccc2c1=O)c1cc(F)cc(F)c1
Structure:
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